The dichotomy between microscopic and macroscopic reminds of the Popperian “demarcation problem” and the associated difficulty to define a set of criteria which separates pseudo-science from science.
Atmanspacher, H. (1997). Cartesian cut, Heisenberg cut, and the concept of complexity. World Futures, 49(3), 333–355. https://doi.org/10.1080/02604027.1997.9972639